Epigenetic silencing and deletion of the BRCA1 gene in sporadic breast cancer

INTRODUCTION: BRCA1 or BRCA2 germline mutations increase the risk of developing breast cancer. Tumour cells from germline mutation carriers have frequently lost the wild-type allele. This is predicted to result in genomic instability where cell survival depends upon dysfunctional checkpoint mechanis...

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Hauptverfasser: Birgisdottir, Valgerdur, Stefansson, Olafur A, Bodvarsdottir, Sigridur K, Hilmarsdottir, Holmfridur, Jonasson, Jon G, Eyfjord, Jorunn E
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779478/
https://ncbi.nlm.nih.gov/pubmed/16846527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr1522
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