BRCA1 Promoter Methylation Status in 1031 Primary Breast Cancers Predicts Favorable Outcomes Following Chemotherapy

BACKGROUND: Breast Cancer 1 gene (BRCA1) is known to be inactivated in breast tumors by promoter methylation. Tumor cells in patients carrying a germline mutation in BRCA1 are sensitive to cytotoxic drugs that cause DNA double strand breaks. However, very little is known on whether patients with BRC...

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Détails bibliographiques
Publié dans:JNCI Cancer Spectr
Auteurs principaux: Stefansson, Olafur A, Hilmarsdottir, Holmfridur, Olafsdottir, Kristrun, Tryggvadottir, Laufey, Sverrisdottir, Asgerdur, Johannsson, Oskar T, Jonasson, Jon G, Eyfjord, Jorunn E, Sigurdsson, Stefan
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061679/
https://ncbi.nlm.nih.gov/pubmed/32175521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jncics/pkz100
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