CpG island hypermethylation of BRCA1 and loss of pRb as co-occurring events in basal/triple-negative breast cancer

Triple-negative breast cancer (TNBC) occurs in approximately 15% of all breast cancer patients, and the incidence of TNBC is greatly increased in BRCA1 mutation carriers. This study aimed to assess the impact of BRCA1 promoter methylation with respect to breast cancer subtypes in sporadic disease. T...

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Main Authors: Stefansson, Olafur Andri, Jonasson, Jon Gunnlaugur, Olafsdottir, Kristrun, Hilmarsdottir, Holmfridur, Olafsdottir, Gudridur, Esteller, Manel, Johannsson, Oskar Thor, Eyfjord, Jorunn Erla
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2011
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121973/
https://ncbi.nlm.nih.gov/pubmed/21593597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.6.5.15667
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