A Spontaneous Mutation of the Rat Themis Gene Leads to Impaired Function of Regulatory T Cells Linked to Inflammatory Bowel Disease

Spontaneous or chemically induced germline mutations, which lead to Mendelian phenotypes, are powerful tools to discover new genes and their functions. Here, we report an autosomal recessive mutation that occurred spontaneously in a Brown-Norway (BN) rat colony and was identified as causing marked T...

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Bibliografische gegevens
Hoofdauteurs: Chabod, Marianne, Pedros, Christophe, Lamouroux, Lucille, Colacios, Céline, Bernard, Isabelle, Lagrange, Dominique, Balz-Hara, Daniela, Mosnier, Jean-Francois, Laboisse, Christian, Vergnolle, Nathalie, Andreoletti, Olivier, Roth, Marie-Paule, Liblau, Roland, Fournié, Gilbert J., Saoudi, Abdelhadi, Dejean, Anne S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261907/
https://ncbi.nlm.nih.gov/pubmed/22275874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002461
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