A Spontaneous Mutation of the Rat Themis Gene Leads to Impaired Function of Regulatory T Cells Linked to Inflammatory Bowel Disease

Spontaneous or chemically induced germline mutations, which lead to Mendelian phenotypes, are powerful tools to discover new genes and their functions. Here, we report an autosomal recessive mutation that occurred spontaneously in a Brown-Norway (BN) rat colony and was identified as causing marked T...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chabod, Marianne, Pedros, Christophe, Lamouroux, Lucille, Colacios, Céline, Bernard, Isabelle, Lagrange, Dominique, Balz-Hara, Daniela, Mosnier, Jean-Francois, Laboisse, Christian, Vergnolle, Nathalie, Andreoletti, Olivier, Roth, Marie-Paule, Liblau, Roland, Fournié, Gilbert J., Saoudi, Abdelhadi, Dejean, Anne S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261907/
https://ncbi.nlm.nih.gov/pubmed/22275874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002461
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg