A Spontaneous Mutation of the Rat Themis Gene Leads to Impaired Function of Regulatory T Cells Linked to Inflammatory Bowel Disease

Spontaneous or chemically induced germline mutations, which lead to Mendelian phenotypes, are powerful tools to discover new genes and their functions. Here, we report an autosomal recessive mutation that occurred spontaneously in a Brown-Norway (BN) rat colony and was identified as causing marked T...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chabod, Marianne, Pedros, Christophe, Lamouroux, Lucille, Colacios, Céline, Bernard, Isabelle, Lagrange, Dominique, Balz-Hara, Daniela, Mosnier, Jean-Francois, Laboisse, Christian, Vergnolle, Nathalie, Andreoletti, Olivier, Roth, Marie-Paule, Liblau, Roland, Fournié, Gilbert J., Saoudi, Abdelhadi, Dejean, Anne S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2012
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261907/
https://ncbi.nlm.nih.gov/pubmed/22275874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002461
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