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An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

Chromosomal translocations arise from the misjoining of DNA breaks, but the identity of the DNA repair factors and activities involved in their formation has been elusive. Here we show that depletion of CtIP, a DNA end-resection factor, results in a substantial decrease in chromosomal translocation...

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Hlavní autoři: Zhang, Yu, Jasin, Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261752/
https://ncbi.nlm.nih.gov/pubmed/21131978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1940
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