Redox regulation of soluble epoxide hydrolase by 15-deoxy-Δ-prostaglandin J(2) controls coronary hypoxic vasodilation

RATIONALE: 15-deoxy-Δ-prostaglandin J(2) (15d-PGJ(2)) is an electrophilic oxidant that dilates the coronary vasculature. This lipid can adduct to redox active protein thiols to induce oxidative post-translational modifications that modulate protein and tissue function. OBJECTIVE: To investigate the...

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Main Authors: Charles, Rebecca L., Burgoyne, Joseph R., Mayr, Manuel, Weldon, Steven M., Hubner, Norbert, Dong, Hua, Morisseau, Christophe, Hammock, Bruce D., Landar, Aimee L., Eaton, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259859/
https://ncbi.nlm.nih.gov/pubmed/21164107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.235879
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