Mitochondrial targeting of the electrophilic lipid 15-deoxy-Δ(12,14)-Prostaglandin J(2) increases apoptotic efficacy via redox cell signaling mechanisms

Prototypical electrophiles such as the lipid 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) are well recognized for their therapeutic potential. Electrophiles modify signaling proteins in both the cytosol and mitochondrion which results in diverse cellular responses including cytoprotective effec...

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Detalhes bibliográficos
Main Authors: Diers, Anne R., Higdon, Ashlee N., Ricart, Karina C., Johnson, Michelle S., Agarwal, Anupam, Kalyanaraman, B., Landar, Aimee, Darley-Usmar, Victor M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3079364/
https://ncbi.nlm.nih.gov/pubmed/19916962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20091293
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