Accumulation of 15-deoxy-Δ(12,14)-prostaglandin J(2) adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defense induction

The cyclooxygenase (COX) pathway generates the reactive lipid electrophile 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)), which forms covalent protein adducts that modulate cell signaling pathways. It has been shown that this regulates important biological responses, including protection against...

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Hauptverfasser: Oh, Joo Yeun, Giles, Niroshini, Landar, Aimee, Darley-Usmar, Victor
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683789/
https://ncbi.nlm.nih.gov/pubmed/18237271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/bj20071189
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