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Accumulation of 15-deoxy-Δ(12,14)-prostaglandin J(2) adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defense induction
The cyclooxygenase (COX) pathway generates the reactive lipid electrophile 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)), which forms covalent protein adducts that modulate cell signaling pathways. It has been shown that this regulates important biological responses, including protection against...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2683789/ https://ncbi.nlm.nih.gov/pubmed/18237271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/bj20071189 |
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