15-Deoxy-Δ(12,14)-prostaglandin J(2): The endogenous electrophile that induces neuronal apoptosis

Prostaglandin D(2) (PGD(2)), a major cyclooxygenase product in a variety of tissues and cells, readily undergoes dehydration to yield the bioactive cyclopentenone-type PGs of the J(2)-series, such as 15-deoxy-Δ(12,14)-PGJ(2) (15d-PGJ(2)). The observation that the level of 15d-PGJ(2) increased in the...

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Autors principals: Kondo, Mitsuhiro, Shibata, Takahiro, Kumagai, Takeshi, Osawa, Toshihiko, Shibata, Noriyuki, Kobayashi, Makio, Sasaki, Shoichi, Iwata, Makoto, Noguchi, Noriko, Uchida, Koji
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC124237/
https://ncbi.nlm.nih.gov/pubmed/12032289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.112212599
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