15-deoxy-Δ(12,14)-Prostaglandin J(2) inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism

Human soluble epoxide hydrolase (hsEH) is an enzyme responsible for the inactivation of bioactive epoxy fatty acids, and its inhibition is emerging as a promising therapeutical strategy to target hypertension, cardiovascular disease, pain and insulin sensitivity. Here, we uncover the molecular bases...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Abis, Giancarlo, Charles, Rebecca L., Kopec, Jolanta, Yue, Wyatt W., Atkinson, R. Andrew, Bui, Tam T. T., Lynham, Steven, Popova, Simona, Sun, Yin-Biao, Fraternali, Franca, Eaton, Philip, Conte, Maria R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525171/
https://ncbi.nlm.nih.gov/pubmed/31123712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0426-2
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