Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression

The adipocyte-derived cytokine adiponectin is known to exert anti-inflammatory and anti-apoptotic effects. In patients with atherosclerotic cardiovascular disease, circulating levels of adiponectin correlate inversely with those of the proinflammatory, proapoptotic cytokine interleukin (IL)-18. The...

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Main Authors: Chandrasekar, Bysani, Boylston, William H., Venkatachalam, Kaliyamurthi, Webster, Nicholas J. G., Prabhu, Sumanth D., Valente, Anthony J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259831/
https://ncbi.nlm.nih.gov/pubmed/18632660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804236200
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