Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

AMP-activated protein kinase (AMPK) serves as an energy sensor and is considered a promising drug target for treatment of type II diabetes and obesity. A previous report has shown that mammalian AMPK α1 catalytic subunit including autoinhibitory domain was inactive. To test the hypothesis that small...

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Detalhes bibliográficos
Main Authors: Pang, Tao, Zhang, Zhen-Shan, Gu, Min, Qiu, Bei-Ying, Yu, Li-Fang, Cao, Peng-Rong, Shao, Wei, Su, Ming-Bo, Li, Jing-Ya, Nan, Fa-Jun, Li, Jia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259642/
https://ncbi.nlm.nih.gov/pubmed/18321858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710114200
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