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Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells
AMP-activated protein kinase (AMPK) serves as an energy sensor and is considered a promising drug target for treatment of type II diabetes and obesity. A previous report has shown that mammalian AMPK α1 catalytic subunit including autoinhibitory domain was inactive. To test the hypothesis that small...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259642/ https://ncbi.nlm.nih.gov/pubmed/18321858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710114200 |
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