Homo-oligomerization and Activation of AMP-activated Protein Kinase Are Mediated by the Kinase Domain αG-Helix

AMP-activated protein kinase (AMPK) is a heterotrimeric complex playing a crucial role in maintaining cellular energy homeostasis. Recently, homodimerization of mammalian AMPK and yeast ortholog SNF1 was shown by us and others. In SNF1, it involved specific hydrophobic residues in the kinase domain...

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Autores principales: Scholz, Roland, Suter, Marianne, Weimann, Théodore, Polge, Cécile, Konarev, Petr V., Thali, Ramon F., Tuerk, Roland D., Viollet, Benoit, Wallimann, Theo, Schlattner, Uwe, Neumann, Dietbert
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Enzyme Catalysis and Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785672/
https://ncbi.nlm.nih.gov/pubmed/19651772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047670
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