Homo-oligomerization and Activation of AMP-activated Protein Kinase Are Mediated by the Kinase Domain αG-Helix

AMP-activated protein kinase (AMPK) is a heterotrimeric complex playing a crucial role in maintaining cellular energy homeostasis. Recently, homodimerization of mammalian AMPK and yeast ortholog SNF1 was shown by us and others. In SNF1, it involved specific hydrophobic residues in the kinase domain...

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Bibliographische Detailangaben
Hauptverfasser: Scholz, Roland, Suter, Marianne, Weimann, Théodore, Polge, Cécile, Konarev, Petr V., Thali, Ramon F., Tuerk, Roland D., Viollet, Benoit, Wallimann, Theo, Schlattner, Uwe, Neumann, Dietbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Enzyme Catalysis and Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785672/
https://ncbi.nlm.nih.gov/pubmed/19651772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047670
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