Homo-oligomerization and Activation of AMP-activated Protein Kinase Are Mediated by the Kinase Domain αG-Helix

AMP-activated protein kinase (AMPK) is a heterotrimeric complex playing a crucial role in maintaining cellular energy homeostasis. Recently, homodimerization of mammalian AMPK and yeast ortholog SNF1 was shown by us and others. In SNF1, it involved specific hydrophobic residues in the kinase domain...

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Detalhes bibliográficos
Main Authors: Scholz, Roland, Suter, Marianne, Weimann, Théodore, Polge, Cécile, Konarev, Petr V., Thali, Ramon F., Tuerk, Roland D., Viollet, Benoit, Wallimann, Theo, Schlattner, Uwe, Neumann, Dietbert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785672/
https://ncbi.nlm.nih.gov/pubmed/19651772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047670
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