The Kinetics of p53 Activation Versus Cyclin E Accumulation Underlies the Relationship between the Spindle-assembly Checkpoint and the Postmitotic Checkpoint

Although cells can exit mitotic block aberrantly by mitotic slippage, they are prevented from becoming tetraploids by a p53-dependent postmitotic checkpoint. Intriguingly, disruption of the spindle-assembly checkpoint also compromises the postmitotic checkpoint. The precise mechanism of the interpla...

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Autors principals: Chan, Ying Wai, On, Kin Fan, Chan, Wan Mui, Wong, Winnie, Siu, Ho On, Hau, Pok Man, Poon, Randy Y. C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Molecular Basis of Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259627/
https://ncbi.nlm.nih.gov/pubmed/18400748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800629200
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