DNA Damage during the Spindle-Assembly Checkpoint Degrades CDC25A, Inhibits Cyclin–CDC2 Complexes, and Reverses Cells to Interphase

Cell cycle checkpoints that monitor DNA damage and spindle assembly are essential for the maintenance of genetic integrity, and drugs that target these checkpoints are important chemotherapeutic agents. We have examined how cells respond to DNA damage while the spindle-assembly checkpoint is activat...

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Main Authors: Chow, Jeremy P.H., Siu, Wai Yi, Fung, Tsz Kan, Chan, Wan Mui, Lau, Anita, Arooz, Talha, Ng, Chuen-Pei, Yamashita, Katsumi, Poon, Randy Y.C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2003
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC206994/
https://ncbi.nlm.nih.gov/pubmed/14517313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-03-0168
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