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How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer?

The tumor suppressor p53 is transcription factor composed of four identical subunits. The majority of the mutations in p53 are missense mutations that impair DNA binding. On the other hand, the p53-related p63 and p73 genes are rarely mutated, but many cell types express natural variants lacking the...

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Bibliografski detalji
Izdano u:Mol Cell Biol
Glavni autori: Chan, Wan Mui, Siu, Wai Yi, Lau, Anita, Poon, Randy Y. C.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2004
Teme:
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381690/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15060172/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.8.3536-3551.2004
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