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How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer?

The tumor suppressor p53 is transcription factor composed of four identical subunits. The majority of the mutations in p53 are missense mutations that impair DNA binding. On the other hand, the p53-related p63 and p73 genes are rarely mutated, but many cell types express natural variants lacking the...

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Detalhes bibliográficos
Main Authors: Chan, Wan Mui, Siu, Wai Yi, Lau, Anita, Poon, Randy Y. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC381690/
https://ncbi.nlm.nih.gov/pubmed/15060172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.8.3536-3551.2004
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