How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer?

The tumor suppressor p53 is transcription factor composed of four identical subunits. The majority of the mutations in p53 are missense mutations that impair DNA binding. On the other hand, the p53-related p63 and p73 genes are rarely mutated, but many cell types express natural variants lacking the...

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Autors principals: Chan, Wan Mui, Siu, Wai Yi, Lau, Anita, Poon, Randy Y. C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC381690/
https://ncbi.nlm.nih.gov/pubmed/15060172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.8.3536-3551.2004
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