How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer?

The tumor suppressor p53 is transcription factor composed of four identical subunits. The majority of the mutations in p53 are missense mutations that impair DNA binding. On the other hand, the p53-related p63 and p73 genes are rarely mutated, but many cell types express natural variants lacking the...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell Biol
Egile Nagusiak: Chan, Wan Mui, Siu, Wai Yi, Lau, Anita, Poon, Randy Y. C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2004
Gaiak:
Cell Growth and Development
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381690/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15060172/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.8.3536-3551.2004
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