How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer?

The tumor suppressor p53 is transcription factor composed of four identical subunits. The majority of the mutations in p53 are missense mutations that impair DNA binding. On the other hand, the p53-related p63 and p73 genes are rarely mutated, but many cell types express natural variants lacking the...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Chan, Wan Mui, Siu, Wai Yi, Lau, Anita, Poon, Randy Y. C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2004
Pynciau:
Cell Growth and Development
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381690/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15060172/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.8.3536-3551.2004
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