Non-Depleting Anti-CD40-Based Therapy Prolongs Allograft Survival in Nonhuman Primates

Costimulation blockade of the CD40/CD154 pathway has been effective at preventing allograft rejection in numerous transplantation models. This strategy has largely depended on mAbs directed against CD154, limiting the potential for translation due to its association with thromboembolic events. Thoug...

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Hauptverfasser: Badell, IR, Thompson, PW, Turner, AP, Russell, MC, Avila, JG, Cano, JA, Robertson, JM, Leopardi, FV, Strobert, EA, Iwakoshi, NN, Reimann, KA, Ford, ML, Kirk, AD, Larsen, CP
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259281/
https://ncbi.nlm.nih.gov/pubmed/21920020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2011.03736.x
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