Alanine Scanning of a Putative Receptor Binding Surface of Insulin-like Growth Factor-I

Current evidence supports a binding model in which the insulin molecule contains two binding surfaces, site 1 and site 2, which contact the two halves of the insulin receptor. The interaction of these two surfaces with the insulin receptor results in a high affinity cross-linking of the two receptor...

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Hlavní autoři: Gauguin, Lisbeth, Delaine, Carlie, Alvino, Clair L., McNeil, Kerrie A., Wallace, John C., Forbes, Briony E., De Meyts, Pierre
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258947/
https://ncbi.nlm.nih.gov/pubmed/18502759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802620200
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