Fusion of OTT to BSAC Results in Aberrant Up-regulation of Transcriptional Activity

OTT/RBM15-BSAC/MAL/MKL1/MRTF-A was identified as a fusion transcript generated by t(1;22)(p13;q13) in acute megakaryoblastic leukemia. Previous studies have shown that BSAC (basic, SAP, and coiled-coil domain) activates the promoters containing CArG boxes via interaction with serum response factor,...

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Hauptverfasser: Sawada, Taisuke, Nishiyama, Chiharu, Kishi, Takuma, Sasazuki, Tomonari, Komazawa-Sakon, Sachiko, Xue, Xin, Piao, Jiang-Hu, Ogata, Hideko, Nakayama, Jun-ichi, Taki, Tomohiko, Hayashi, Yasuhide, Watanabe, Mamoru, Yagita, Hideo, Okumura, Ko, Nakano, Hiroyasu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Transcription, Chromatin, and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258922/
https://ncbi.nlm.nih.gov/pubmed/18667423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802315200
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