c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis

As a catalytically inactive homolog of caspase-8, a proapoptotic initiator caspase, c-FLIP blocks apoptosis by binding to and inhibiting caspase-8. The transcription factor nuclear factor κB (NF-κB) plays a pivotal role in maintaining the homeostasis of the intestine and the liver by preventing deat...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Piao, Xuehua, Komazawa-Sakon, Sachiko, Nishina, Takashi, Koike, Masato, Piao, Jiang-Hu, Ehlken, Hanno, Kurihara, Hidetake, Hara, Mutsuko, Van Rooijen, Nico, Schütz, Günther, Ohmuraya, Masaki, Uchiyama, Yasuo, Yagita, Hideo, Okumura, Ko, He, You-Wen, Nakano, Hiroyasu
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465294/
https://ncbi.nlm.nih.gov/pubmed/23250397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003558
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