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Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

NF-κB is activated by various stimuli including inflammatory cytokines and stresses. A key step in the activation of NF-κB is the phosphorylation of its inhibitors, IκBs, by an IκB kinase (IKK) complex. Recently, two closely related kinases, designated IKKα and IKKβ, have been identified to be the c...

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Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Nakano, Hiroyasu, Shindo, Masahisa, Sakon, Sachiko, Nishinaka, Shigeyuki, Mihara, Motoyuki, Yagita, Hideo, Okumura, Ko
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 1998
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19871/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9520401/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.7.3537
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