Lck-dependent Fyn Activation Requires C Terminus-dependent Targeting of Kinase-active Lck to Lipid Rafts

Mechanisms regulating the activation and delivery of function of Lck and Fyn are central to the generation of the most proximal signaling events emanating from the T cell antigen receptor (TcR) complex. Recent results demonstrate that lipid rafts (LR) segregate Lck and Fyn and play a fundamental rol...

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Bibliografiske detaljer
Main Authors: Filipp, Dominik, Moemeni, Behrouz, Ferzoco, Alessandra, Kathirkamathamby, Kirishanthy, Zhang, Jenny, Ballek, Ondřej, Davidson, Dominique, Veillette, André, Julius, Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258908/
https://ncbi.nlm.nih.gov/pubmed/18660530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710372200
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