TCR Triggering Induces the Formation of Lck–RACK1–Actinin-1 Multiprotein Network Affecting Lck Redistribution

The initiation of T-cell signaling is critically dependent on the function of the member of Src family tyrosine kinases, Lck. Upon T-cell antigen receptor (TCR) triggering, Lck kinase activity induces the nucleation of signal-transducing hubs that regulate the formation of complex signaling network...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Ballek, Ondřej, Valečka, Jan, Dobešová, Martina, Broučková, Adéla, Manning, Jasper, Řehulka, Pavel, Stulík, Jiří, Filipp, Dominik
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081367/
https://ncbi.nlm.nih.gov/pubmed/27833610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00449
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