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Malaria-Infected Mice are Completely Cured by One 6 mg/kg Oral Dose of a New Monomeric Trioxane Sulfide Combined with Mefloquine

Sixteen new anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in Plasmodium berghei-infected mice. Of these sixteen new anilides administered orally as one 6 mg/kg dose combined with 18 mg/kg mefloquine hydrochloride, only sulfide 3-arteSan...

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書誌詳細
主要な著者: Slack, Rachel D., Mott, Bryan T., Woodard, Lauren E., Triphati, Abhai, Sullivan, David, Nenortas, Elizabeth, Girdwood, Sonya C. T., Shapiro, Theresa A., Posner, Gary H.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257372/
https://ncbi.nlm.nih.gov/pubmed/22128829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201214d
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