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A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice

Four 5-carbon-linked trioxane dimer orthoesters (6a–6d) have been prepared in 4 or 5 chemical steps from the natural trioxane artemisinin (1). When administered orally to malaria-infected mice using a single dose of only 6 mg/kg body weight along with 18 mg/kg of mefloquine hydrochloride, trioxane d...

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Autors principals: Moon, Deuk Kyu, Tripathi, Abhai, Sullivan, David, Siegler, Maxime A., Parkin, Sean, Posner, Gary H.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037442/
https://ncbi.nlm.nih.gov/pubmed/20952197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.09.123
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