Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region

Hematopoietic stem cells (HSCs) emerge during embryogenesis and maintain hematopoiesis in the adult organism. Little is known about the embryonic development of human HSCs. We demonstrate that human HSCs emerge first in the aorta-gonad-mesonephros (AGM) region, specifically in the dorsal aorta, and...

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Main Authors: Ivanovs, Andrejs, Rybtsov, Stanislav, Welch, Lindsey, Anderson, Richard A., Turner, Marc L., Medvinsky, Alexander
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256972/
https://ncbi.nlm.nih.gov/pubmed/22042975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111688
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