Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros–derived hematopoietic stem cells

Hematopoietic stem cells (HSCs) first emerge during embryonic development within vessels such as the dorsal aorta of the aorta-gonad-mesonephros (AGM) region, suggesting that signals from the vascular microenvironment are critical for HSC development. Here, we demonstrated that AGM-derived endotheli...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Hadland, Brandon K., Varnum-Finney, Barbara, Poulos, Michael G., Moon, Randall T., Butler, Jason M., Rafii, Shahin, Bernstein, Irwin D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463208/
https://ncbi.nlm.nih.gov/pubmed/25866967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80137
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