Prothymosin-α Interacts with Mutant Huntingtin and Suppresses Its Cytotoxicity in Cell Culture

Huntington disease (HD), a fatal neurodegenerative disorder, is caused by a lengthening of the polyglutamine tract in the huntingtin (Htt) protein. Despite considerable effort, thus far there is no cure or treatment available for the disorder. Using the approach of tandem affinity purification we re...

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Bibliografske podrobnosti
Main Authors: Dong, Gaofeng, Callegari, Eduardo A., Gloeckner, Christian J., Ueffing, Marius, Wang, Hongmin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256907/
https://ncbi.nlm.nih.gov/pubmed/22110140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.294280
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