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Mass Spectrometric Identification of Novel Posttranslational Modification Sites in Huntingtin
Huntington’s disease (HD) is caused by a CAG triplet repeat expansion in exon 1 of the Huntingtin (Htt) gene, encoding an abnormal expanded polyglutamine (polyQ) tract that confers toxicity to the mutant Htt (mHtt) protein. Recent data suggest that posttranslational modifications of mHtt modulate it...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3845347/ https://ncbi.nlm.nih.gov/pubmed/22623107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201100380 |
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