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Mass Spectrometric Identification of Novel Posttranslational Modification Sites in Huntingtin

Huntington’s disease (HD) is caused by a CAG triplet repeat expansion in exon 1 of the Huntingtin (Htt) gene, encoding an abnormal expanded polyglutamine (polyQ) tract that confers toxicity to the mutant Htt (mHtt) protein. Recent data suggest that posttranslational modifications of mHtt modulate it...

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Detalhes bibliográficos
Main Authors: Dong, Gaofeng, Callegari, Eduardo, Gloeckner, Christian J., Ueffing, Marius, Wang, Hongmin
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845347/
https://ncbi.nlm.nih.gov/pubmed/22623107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201100380
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