Modulation of Heme/Substrate Binding Cleft of Neuronal Nitric-oxide Synthase (nNOS) Regulates Binding of Hsp90 and Hsp70 Proteins and nNOS Ubiquitination

Like other nitric-oxide synthase (NOS) enzymes, neuronal NOS (nNOS) turnover and activity are regulated by the Hsp90/Hsp70-based chaperone machinery, which regulates signaling proteins by modulating ligand binding clefts (Pratt, W. B., Morishima, Y., and Osawa, Y. (2008) J. Biol. Chem. 283, 22885–22...

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Bibliographic Details
Main Authors: Peng, Hwei-Ming, Morishima, Yoshihiro, Pratt, William B., Osawa, Yoichi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256889/
https://ncbi.nlm.nih.gov/pubmed/22128174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.323295
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