Dose escalation of intravenous irinotecan using oral cefpodoxime: a phase I study in pediatric patients with refractory solid tumors

BACKGROUND: Administration of an oral cephalosporin allowed advancement of the dosage of oral irinotecan. This study investigates whether administration of an oral cephalosporin increases the maximum tolerated dose (MTD) of intravenous irinotecan. PROCEDURE: Irinotecan was administered intravenously...

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Detalhes bibliográficos
Main Authors: McGregor, Lisa M., Stewart, Clinton F., Crews, Kristine R., Tagen, Michael, Wozniak, Amy, Wu, Jianrong, McCarville, M. Beth, Navid, Fariba, Santana, Victor M., Houghton, Peter J., Furman, Wayne L., Galindo, Carlos Rodriguez
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256281/
https://ncbi.nlm.nih.gov/pubmed/21509928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23075
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