Dose escalation of intravenous irinotecan using oral cefpodoxime: a phase I study in pediatric patients with refractory solid tumors

BACKGROUND: Administration of an oral cephalosporin allowed advancement of the dosage of oral irinotecan. This study investigates whether administration of an oral cephalosporin increases the maximum tolerated dose (MTD) of intravenous irinotecan. PROCEDURE: Irinotecan was administered intravenously...

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Bibliografiska uppgifter
Huvudupphovsmän: McGregor, Lisa M., Stewart, Clinton F., Crews, Kristine R., Tagen, Michael, Wozniak, Amy, Wu, Jianrong, McCarville, M. Beth, Navid, Fariba, Santana, Victor M., Houghton, Peter J., Furman, Wayne L., Galindo, Carlos Rodriguez
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256281/
https://ncbi.nlm.nih.gov/pubmed/21509928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23075
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