Dose escalation of intravenous irinotecan using oral cefpodoxime: a phase I study in pediatric patients with refractory solid tumors

BACKGROUND: Administration of an oral cephalosporin allowed advancement of the dosage of oral irinotecan. This study investigates whether administration of an oral cephalosporin increases the maximum tolerated dose (MTD) of intravenous irinotecan. PROCEDURE: Irinotecan was administered intravenously...

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Main Authors: McGregor, Lisa M., Stewart, Clinton F., Crews, Kristine R., Tagen, Michael, Wozniak, Amy, Wu, Jianrong, McCarville, M. Beth, Navid, Fariba, Santana, Victor M., Houghton, Peter J., Furman, Wayne L., Galindo, Carlos Rodriguez
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256281/
https://ncbi.nlm.nih.gov/pubmed/21509928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23075
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