A Single-Arm Pilot Phase II Study of Gefitinib and Irinotecan in Children with Newly Diagnosed High-Risk Neuroblastoma

BACKGROUND: Gefitinib potently inhibits neuroblastoma proliferation in vitro, and the gefitinib/irinotecan combination shows greater than additive activity against neuroblastoma xenografts. This Phase II pilot study estimated the rate of response to two courses of intravenous irinotecan plus oral ge...

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Autori principali: Furman, Wayne L., McGregor, Lisa M., McCarville, M. Beth, Onciu, Mihaela, Davidoff, Andrew M., Kovach, Sandy, Hawkins, Dana, McPherson, Valerie, Houghton, Peter J., Billups, Catherine A., Wu, Jianrong, Stewart, Clinton F., Santana, Victor M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232294/
https://ncbi.nlm.nih.gov/pubmed/21796439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-011-9724-3
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