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IκB Kinase ε-Dependent Phosphorylation and Degradation of X-Linked Inhibitor of Apoptosis Sensitizes Cells to Virus-Induced Apoptosis

X-linked inhibitor of apoptosis (XIAP) is a potent antagonist of caspase 3-, 7-, and 9-dependent apoptotic activities that functions as an E3 ubiquitin ligase, and it targets caspases for degradation. In this study, we demonstrate that Sendai virus (SeV) infection results in the IKKε- or TBK1-mediat...

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Detalhes bibliográficos
Main Authors: Nakhaei, Peyman, Sun, Qiang, Solis, Mayra, Mesplede, Thibault, Bonneil, Eric, Paz, Suzanne, Lin, Rongtuan, Hiscott, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255812/
https://ncbi.nlm.nih.gov/pubmed/22072751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05989-11
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