IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells

Interferon Regulatory Factors (IRFs) are key regulators of immunity, cell survival and apoptosis. IRF transcriptional activity and subcellular localization are tightly regulated by posttranscriptional modifications including phosphorylation. The IκB kinase family member IKK-ε is essential in regulat...

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Publicat a:Neoplasia
Autors principals: Remoli, Anna Lisa, Sgarbanti, Marco, Perrotti, Edvige, Acchioni, Marta, Orsatti, Roberto, Acchioni, Chiara, Battistini, Angela, Clarke, Robert, Marsili, Giulia
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press 2020
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Original article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419274/
https://ncbi.nlm.nih.gov/pubmed/32784074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2020.07.004
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