IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells

Interferon Regulatory Factors (IRFs) are key regulators of immunity, cell survival and apoptosis. IRF transcriptional activity and subcellular localization are tightly regulated by posttranscriptional modifications including phosphorylation. The IκB kinase family member IKK-ε is essential in regulat...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Remoli, Anna Lisa, Sgarbanti, Marco, Perrotti, Edvige, Acchioni, Marta, Orsatti, Roberto, Acchioni, Chiara, Battistini, Angela, Clarke, Robert, Marsili, Giulia
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2020
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419274/
https://ncbi.nlm.nih.gov/pubmed/32784074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2020.07.004
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