IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells

Interferon Regulatory Factors (IRFs) are key regulators of immunity, cell survival and apoptosis. IRF transcriptional activity and subcellular localization are tightly regulated by posttranscriptional modifications including phosphorylation. The IκB kinase family member IKK-ε is essential in regulat...

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Pubblicato in:Neoplasia
Autori principali: Remoli, Anna Lisa, Sgarbanti, Marco, Perrotti, Edvige, Acchioni, Marta, Orsatti, Roberto, Acchioni, Chiara, Battistini, Angela, Clarke, Robert, Marsili, Giulia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2020
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Original article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419274/
https://ncbi.nlm.nih.gov/pubmed/32784074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2020.07.004
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