The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

The primary role of the innate immune response is to limit the spread of infectious pathogens, with activation of Toll-like receptor (TLR) and RIG-like receptor (RLR) pathways resulting in a pro-inflammatory response required to combat infection. Limiting the activation of these signaling pathways i...

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Detalhes bibliográficos
Main Authors: Nakhaei, Peyman, Mesplede, Thibault, Solis, Mayra, Sun, Qiang, Zhao, Tiejun, Yang, Long, Chuang, Tsung-Hsien, Ware, Carl F., Lin, Rongtuan, Hiscott, John
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766052/
https://ncbi.nlm.nih.gov/pubmed/19893624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000650
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