Monoclonal Antibody-Based Antigenic Mapping of Norovirus GII.4-2002

Noroviruses are the primary cause of epidemic gastroenteritis in humans, and GII.4 strains cause ∼80% of the overall disease burden. Surrogate neutralization assays using sera and mouse monoclonal antibodies (MAbs) suggest that antigenic variation maintains GII.4 persistence in the face of herd immu...

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Autors principals: Lindesmith, Lisa C., Debbink, Kari, Swanstrom, Jesica, Vinjé, Jan, Costantini, Verónica, Baric, Ralph S., Donaldson, Eric F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255811/
https://ncbi.nlm.nih.gov/pubmed/22090098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06200-11
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