Effects of Age and Amyloid Deposition on Aβ Dynamics in the Human Central Nervous System

OBJECTIVE: The amyloid hypothesis predicts that increased production or decreased clearance of amyloid beta (Aβ) leads to amyloidosis, ultimately culminating in Alzheimer’s disease (AD). Dynamic changes in human CNS Aβ levels may be altered by aging or AD pathology and contribute to the risk of AD....

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Autors principals: Huang, Yafei, Potter, Rachel, Sigurdson, Wendy, Santacruz, Anna, Shih, Shirley, Ju, Yo-El, Kasten, Tom, Morris, John C., Mintun, Mark, Duntley, Stephen, Bateman, Randall J.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254706/
https://ncbi.nlm.nih.gov/pubmed/21911660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archneurol.2011.235
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