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Total Synthesis of (+)-7-Bromotrypargine and Unnatural Analogues: Biological Evaluation Uncovers Activity at CNS Targets of Therapeutic Relevance

[Image: see text] The first total synthesis of (+)-7-bromotrypargine, a β-carboline alkaloid from Ancornia sp. is reported. The synthesis proceeds in nine steps, eight steps longest linear sequence, in 36.9% overall yield. Biological characterization found that (+)-7-bromotrypargine is a H(3) antago...

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Main Authors: Brogan, John T., Stoops, Sydney L., Crews, Brenda C., Marnett, Lawrence J., Lindsley, Craig W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2011
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254090/
https://ncbi.nlm.nih.gov/pubmed/22247792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200075n
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