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Total Synthesis and Biological Evaluation of Phidianidines A and B Uncovers Unique Pharmacological Profiles at CNS Targets

[Image: see text] The synthesis of phidianidines A and B, the first 1,2,4-oxadiazole-containing alkaloid, from the marine opisthobranch mollusk Phidiana militaris is reported. The synthesis proceeds in six steps from known indole acetic acids in 39.9% (phidianidine A) and 21% (phidianidine B) overal...

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Xehetasun bibliografikoak
Egile Nagusiak: Brogan, John T., Stoops, Sydney L., Lindsley, Craig W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2012
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447392/
https://ncbi.nlm.nih.gov/pubmed/23019492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300064r
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