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The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together

Proteasomes execute the degradation of most cellular proteins. Although the 20S core particle (CP) has been studied in great detail, the structure of the 19S regulatory particle (RP), which prepares ubiquitylated substrates for degradation, has remained elusive. Here, we report the crystal structure...

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Detalhes bibliográficos
Main Authors: Pathare, Ganesh Ramnath, Nagy, István, Bohn, Stefan, Unverdorben, Pia, Hubert, Agnes, Körner, Roman, Nickell, Stephan, Lasker, Keren, Sali, Andrej, Tamura, Tomohiro, Nishioka, Taiki, Förster, Friedrich, Baumeister, Wolfgang, Bracher, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252951/
https://ncbi.nlm.nih.gov/pubmed/22187461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117648108
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