The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together

Proteasomes execute the degradation of most cellular proteins. Although the 20S core particle (CP) has been studied in great detail, the structure of the 19S regulatory particle (RP), which prepares ubiquitylated substrates for degradation, has remained elusive. Here, we report the crystal structure...

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Detaylı Bibliyografya
Asıl Yazarlar: Pathare, Ganesh Ramnath, Nagy, István, Bohn, Stefan, Unverdorben, Pia, Hubert, Agnes, Körner, Roman, Nickell, Stephan, Lasker, Keren, Sali, Andrej, Tamura, Tomohiro, Nishioka, Taiki, Förster, Friedrich, Baumeister, Wolfgang, Bracher, Andreas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2012
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252951/
https://ncbi.nlm.nih.gov/pubmed/22187461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117648108
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