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A Mathematical Methodology for Determining the Temporal Order of Pathway Alterations Arising during Gliomagenesis

Human cancer is caused by the accumulation of genetic alterations in cells. Of special importance are changes that occur early during malignant transformation because they may result in oncogene addiction and thus represent promising targets for therapeutic intervention. We have previously described...

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Hlavní autoři: Cheng, Yu-Kang, Beroukhim, Rameen, Levine, Ross L., Mellinghoff, Ingo K., Holland, Eric C., Michor, Franziska
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252265/
https://ncbi.nlm.nih.gov/pubmed/22241976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002337
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